CMTM6 maintains the expression of PD-L1 and regulates

Aug 16, 2017 · CMTM6 is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression. CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L1 at the plasma membrane cmtm6 maintains the eion of pd

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CMTM6 maintains the expression of PD-L1 and regulates

Aug 16, 2017 · CMTM6 is a ubiquitously expressed, protein that binds PD-L1 and maintains its cell surface expression. CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L1 at the plasma membrane and in recycling endosomes where it prevents PD-L1 from being targeted for lysosome-mediated degradation.

Cited by 198

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CMTM6, the newly identified PD-L1 regulator, correlates cmtm6 maintains the eion of pd

The newly identified regulator CMTM6 (CKLF-like MARVEL transmembrane domain containing 6) has been reported to serves as the stabilizer of PD-L1 and enhances the inhibitory effect of PD-L1 on immune system in both cell line and animal models, but its clinical relevance associated with PD-L1 is unknown and the current study is designed to address this question.

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Frontiers Expression Analysis of Canine CMTM6 and

Jun 11, 2020 · Recent reports have shown that CMTM6 and CMTM4 are critical regulators of PD-L1 protein expression in human cancer cells. By preventing PD-L1 from lysosome-mediated degradation, CMTM6 maintains PD-L1 expression on the cell surface. However, the literature has not reported on CMTM6 and CMTM4 in dogs, and their functions are completely unknown.

Author Hiroto Takeuchi, Satoru Konnai, Naoya Maekawa, Erina Minato, Yoshiki Ichikawa, Atsushi Kobayashi, To cmtm6 maintains the eion of pd

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CMTM6 stabilizes PD-L1 expression and refines its cmtm6 maintains the eion of pd

The dissection of this pathway revealed that CMTM6 protects PD-L1 from ubiquitination, thus resulting in the increase of PD-L1 protein half-life at the cell membrane and in recycling endosomes, where it prevents PD-L1 from being targeted for lysosome-mediated degradation.

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CMTM6 - CKLF-like MARVEL transmembrane domain

CMTM6 is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression. CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L1 at the plasma membrane and in recycling endosomes, where it prevents PD-L1 from being targeted for lysosome-mediated degradation.

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CMTM6 expressed on the adaxonal Schwann cell surface cmtm6 maintains the eion of pd

Burr, M. L. et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 549, 101105 (2017). ADS CAS Article Google Scholar 30. Mezzadra, R. et al. Identification cmtm6 maintains the eion of pd

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CMTM6, the newly identified PD-L1 regulator, correlates cmtm6 maintains the eion of pd

In another report, supporting the idea from above paper, CMTM6 was shown to protect PD-L1 from being targeted by lysosome-mediated degradation and maintain PD-L1 expression on the cell surface. CMTM6 depletion, via the reduction of PD-L1, significantly alleviates the suppression of tumor-specific T cell activity in vitro and in vivo [ 7 ].

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CMTM6 maintains the expression of PD-L1 and regulates

Aug 16, 2017 · Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to subvert T-cell mediated immunosurveillance 1, 2.The success of therapies that disrupt PD-L1 mediated tumour tolerance has highlighted the need to understand the molecular regulation of PD-L1 expression 1.Using a genome-wide CRISPR/Cas9 screen we identified the uncharacterized protein CMTM6 to be

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CMTM6 maintains the expression of PD-L1 and regulates

CMTM6 is a ubiquitously expressed protein that binds PD-L1 and maintains its cell surface expression. CMTM6 is not required for PD-L1 maturation but co-localizes with PD-L1 at the plasma membrane and in recycling endosomes, where it prevents PD-L1 from being targeted for lysosome-mediated degradation.

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CMTM6 maintains the expression of PD-L1 and

CMTM6 for PD-L1 cell surface expression and the physical association between CMTM6 and PD-L1, establish CMTM6 as a new regulatory target to specifically vary the cell surface expression of this critical immune checkpoint molecule. PD-L1 is a type I transmembrane protein with four N-linked glycans

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Novel regulators of PD-L1 expression in cancer CMTM6 and cmtm6 maintains the eion of pd

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 2017;549:101-5. Mezzadra R, Sun C, Jae LT, et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature 2017;549:106-10. Submitted Sep 12, 2017. Accepted for publication Sep 18, 2017. doi 10.21037/atm.2017.09.32

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Identification of CMTM6 and CMTM4 as PD-L1 protein cmtm6 maintains the eion of pd

Aug 16, 2017 · CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells. PD-1/PD-L1 blocking antibodies are effective in

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Molecular and immune characteristics for lung cmtm6 maintains the eion of pd

Jun 01, 2020 · CMTM6 maintains the expression of PD-L1 and regulates anti-tumor immunity. CMTM6 appears to function by reducing ubiquitination and increasing the half-life of PD-L1 protein. Furthermore, CMTM6 knockout, via the reduction of PD-L1, significantly promotes tumor-specific T

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CMTM6 - Antibodies - The Human Protein Atlas

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity Burr ML et al Nature 2017;549(7670):101-105 Application ICC-IF, IP, WB Identification of CMTM6 and CMTM4 as PD-L1 protein regulators Mezzadra R et al Nature 2017;549(7670):106-110 Application IP, WB

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(PDF) Expression Analysis of Canine CMTM6 and CMTM4 as cmtm6 maintains the eion of pd

PDF Cancer is one of the most significant causes of death in dogs. Antibody drugs targeting the PD-1/PD-L1 axis represent a promising immunotherapy cmtm6 maintains the eion of pd Find, read and cite all the research you cmtm6 maintains the eion of pd

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Frontiers Expression Analysis of Canine CMTM6 and

Jun 11, 2020 · Recent reports have shown that CMTM6 and CMTM4 are critical regulators of PD-L1 protein expression in human cancer cells. By preventing PD-L1 from lysosome-mediated degradation, CMTM6 maintains PD-L1 expression on the cell surface. However, the literature has not reported on CMTM6 and CMTM4 in dogs, and their functions are completely unknown.

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CMTM6 overexpression is associated with molecular and cmtm6 maintains the eion of pd

Aug 18, 2018 · CMTM6, a previously uncharacterized protein, was identified as a critical regulator of PD-L1, which is reported as an immune checkpoint inhibitor, to modulate the T cell activities both in vitro and in vivo of other tumors. However, the role of CMTM6 has so far remained unclear in glioma. To investigate the role of CMTM6 in gliomas, we analyzed the transcriptome level, genomic profiles and

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Checkpoint Protein Propped Up by Cell-Surface Sidekick cmtm6 maintains the eion of pd

Aug 21, 2017 · One paper, from the Netherlands Cancer Institute, was entitled Identification of CMTM6 and CMTM4 as PD-L1 Protein Regulators. The other paper, from the Peter MacCallum Cancer Centre, was entitled CMTM6 Maintains the Expression of PD-L1 and Regulates Anti-Tumour Immunity. Each team used a different loss-of-function screening method.

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Multifactorial regulators of tumor programmed death-ligand cmtm6 maintains the eion of pd

Burr ML, Sparbier CE, Chan YC, et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 2017;549:101-5. Lee SJ, Jang BC, Lee SW, et al. Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274). FEBS Lett 2006;580:755-62.

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CD58 - Lymphocyte function-associated antigen 3 precursor cmtm6 maintains the eion of pd

Nov 01, 1990 · Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA

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